Too much clotting: CLOT
C - C/S deficiency
L - Leiden (factor V)
O - Odd (mutated) prO-thrombin
T - anTi-thrombin III deficiency
Too much bleeding: I BLED
I - ITP, ATP, TTP
B - B/A Haemophilias
L - Low vitamin K, clotting factors
E - Eponym: vWD
D - DIC & Drugs
| Cause | Factors affected |
|---|---|
| Heparin | Prevents activation factors 2,9,10,11 |
| Warfarin | Affects synthesis of factors 2,7,9,10 |
| DIC | Factors 1,2,5,8,11 |
| Liver disease | Factors 1,2,5,7,9,10,11 |
Interpretation blood clotting test results
| Disorder | APTT | PT | Bleeding time |
|---|---|---|---|
| Haemophilia | Increased | Normal | Normal |
| von Willebrand’s disease | Increased | Normal | Increased |
| Vitamin K deficiency | Increased | Increased | Normal |