- Abnormally thickened mucous due to chloride channel deletion of a phenylalanine residue - all tubes/mucous places have issues
- Dehydrated mucus that blocks lumen (\rightarrow) infections, inflammation and scarrinng (S. aureus in childhood, Pseudomonas aeruginosa)
- bronchitis, bronchiectasis, pancreas - exocrine aatrophy and fibrosis, seminiferous tubules blockage 95% males infertile
- Chronic cough, lung infections malabsorption and eventual right sided Heart Failure