Gatekeepers - directly regularte tumours gene growth - division and death RB1, APC
**Care takers -**improve genetic stability p53, BRCA1/2, PARP1
Landscape - control surrounding area APC
Familial Adenomatous Polyposis
- APC tumour supressor gene
- Autosomal dominant
- 100% risk of bowel adenoma
Hereidtary Nonpolyposis Colorectal Cancer (Lynch syndrome)
- MLH1, MLH2, MSH6, PMS2, EPCAM
- Autosomal dominant inheritance
- 20-80% risk of bowel adenoma
- DNA mismatch reapir (microsatelites)
BRCA1/2 mutations
- DNA repair genes
- Breast, ovaries, prostate, pancreatic
- Autosomal dominant
Li Fraumeni Syndrome
- p53 mutations
- Autosomal dominant
- Breast, sarcoma, brain, adrenalcortical, leukaemia