| Mechanism | Metabolised to NO in smooth muscle cells Causes vascular smooth muscle relaxation Coronary artery/systemic vein vasodilation |
| Typical Dose | 20-50mg OD |
| Indications | * Angina prophylaxis * HF |
| Contra-indications | * Hypotension * Aortic/mitral stenosis * Contrictive Pericarditis * Hypertrophic obstructive cardiomyopathy * Head trauma/cerebral haemorrhage |
| Side-effects | Headache, dizziness, postural hypotension, flushing, tachycardia |
| Interactions | Sildenafil - ↑ hypotensive effects |
| Elimination | |
| Additional Notes | Tolerance can occur after 24hrs, minimise this by allowing drug-free period of 8 hours |