| Mechanism | Binds and inhibits voltage-gated sodium channels, stabilizing presynaptic neuronal membranes and inhibiting presynaptic glutamate and aspartate release |
| Typical Dose | 25mg for 14 days then 50mg for 14 days then increase by 100mg every 7-14 days |
| Indications | * Partial seizures * Tonic-clonic seizures * Focal seizures * Bipolar disorder * Trigeminal neuralgia |
| Contra-indications | Cautions: Brugada syndrome, Parkinson’s disease, Myoclonic seizure(exacerbating) |
| Side-effects | Common: Rash, agitation, sleep disorders, tremor, N&V |
| Interactions | Ritonavir: decreases the exposure to Lamotrigine |
| Elimination | |
| Additional Notes | |