Increasing age------------------------------------------------------------------⇒
| ALL | CML | AML | CLL |
|---|---|---|---|
| Children T-blast TdT+ B-cell blast = TdT+ & CD10+ | Philadelphia chromosome t(9;22) (CreaM cheese → philadelphia) Tx: imatinib (tyrosine kinase inhibitor) CML can undergo a blast crisis and become AML | Auer rods Myeloperoxidase positive aLL-trans retinoic acid | > 60 years “Crushed little lymphocytes” → smudge cells on peripheral smear |