| Mechanism | Inhibits angiotensin converting enzyme - ↓ angiotensin II synthesis and ↑ bradykinin accumulation |
| Typical Dose | 2.5mg - max 10mg daily |
| Indications | * HTN * HF * Post-MI * Diabetic Nephropathy |
| Contra-indications | * Renal vascular disease (renal artery stenosis) * Aortic Stenosis * Pregnancy (unless essential) |
| Side-effects | Common: postural hypotension, dry cough (switch to ARB), rash Rarely: Hyperkalaemia, decreased renal function |
| Interactions | * Diuretics - pronounced hypotension * Lithium - increased concentration * NSAIDs - risk of renal impairment * K-sparing diuretics - risk of Hyperkalaemia |
| Elimination | |
| Additional Notes | Patients should take 1st dose before bed to avoid 1st dose hypotension. |