Empirical treatment consists of an STI is a STAT dose of IM ceftriaxone to cover for Neisseria gonorrhoeae and a 10-14 day course of oral doxycycline to cover for Chlamydia trachomatis. This treatment reflects the most commonly transmitted bacterial sexually transmitted infections in the UK.
Benzathine penicillin IM single dose is the treatment for a syphilis infection caused by Treponema pallidum.
Oral metronidazole is used in the treatment of Trichomonas vaginalis and bacterial vaginosis
Oral azithromycin was previously given in the treatment of Neisseria gonorrhoeae in combination with IM ceftriaxone. However, new guidelines advocate the treatment of Neisseria gonorrhoeae with IM ceftriaxone alone (unless needle-phobic).