| Ulcerative Colitis | Crohn’s Disease | |
|---|---|---|
| Distribution | Rectum/colon | Any part of GIT |
| Histology | Mucosa/sub-mucosa continuous inflammation, no granuloma | Transmural, granulomas, can be patchy |
| Smoking | Protective? | Worsens |
| EIMs | Yes | Yes |
| Surgery | Pan-proctocolectomy | Depends on distribution |
| Recurrence after surgery | No | Common |
| Peri-anal disease, Fistulae, abcesses | No | Yes |
| Extra-intestinal manifestations | Primary sclerosing cholangitis | Gallstones and renal stones |