Folate synthesis inhibitors
| Antibiotic | Indications | Considerations |
|---|---|---|
| Trimethoprim | Gram -ve UTI, prostatitis | Inhibitors creatinine secretion |
| Co-trimoxazole (sulfamethoxazole + trimethoprim) | Pneumocystis jirovecii, GI infections, protozoans, listeria, nocardia, MRSA | Good oral absorption and CSF penetration |
Fluroquinolones
Ciprofloxacin, levofloxacin, moxifloxacin
- Broad spectrum including Pseudomonas
- CNS effects: seizure threshold, headache, drowsiness, mood change
- Peripheral neuropathy
- QT
Others
| Antibiotic | Indications | Considerations |
|---|---|---|
| Metronidazole | Anaerobic infections: intra-abdominal, pelvic, oral, soft tissue | Good poral absorption, disulfiram reaction with alcohol, inhibitors Warfarin metabolism |
| Rifamycins: rifampicin, rifabutin, rifapentine | Mycobacteria (TB, atypical mycobacteria, leprosy), some Staph, Legionella, meningococcal prophylaxis | Monitor LFTs, red secretions from urine saliva, sweat sputum |