| Mechanism | * Broken down to toxic compounds within microbes with anaerobic/microaerophillic metabolism * Toxic compounds kill microbes by interfering with nucleic acid function and synthesis |
| Typical Dose | 400mg TDS |
| Indications | * Anaerobic protozoal infections * Dental infections * Helicobacter pylori eradication * Rosacea * Pseudomembranous colitis * Foot infection * etc etc |
| Contra-indications | Caution: Pregnancy, breastfeeding, hepatic impairment Avoid exposure to strong sunlight/UV |
| Side-effects | Dry mouth, myalgia, nausea, oral disorders, metallic taste |
| Interactions | Alcohol: causes disulfiram-like reaction (flushing abdo pain hypotension). Must be avoided Warfarin & Phenytoin: increased plasma conc |
| Elimination | |
| Additional Notes | Therapeutic monitoring for course >10 days. Commonly used to treat dental infections |