Cancer of the kidney that arises from nephroblasts (cells that develop into the kidney in embryological development)
Causes/Factors
- Children < 5 y/o
- 5-10% genetic syndromes
- Beckwith-Weidemann Syndrome
- WAGR Syndrome
- Denys-Drash Syndrome (WT1 mutation)
Clinical Features
Local Primary Tumour Effects
- +++ Abdominal distention
- Haematuria
- 10% bilateral
Effects of Distant Metastases
Rare
Paraneoplastic Syndromes
Rare
Diagnostic Tests
Management
- 90% 5YSR