| Mechanism | * Inhibits osteoclast Bone reabsorption * For optimal activity, enough vitamin D and calcium are needed |
| Typical Dose | 10mg OD or 70mg once weekly |
| Indications | * osteoporosis * Paget’s disease |
| Contra-indications | * Abnormalities of the oesophagus (eg structure) * Hypocalcaemia * Other factors which delay emptying |
| Side-effects | * GI disorders * Joint swelling * Vertigo * Osteonecrosis of the (risk factors, malignancy and dental disease) |
| Interactions | Antacids: decrease absorption of alendronate |
| Elimination | |
| Additional Notes | |