| Mechanism | Partial metabolic conversion to Morphine - 1/6 potency |
| Typical Dose | 30-60mg QDS for 3 days max |
| Indications | * Mild-moderate pain * Diarrhoea * Cough suppression |
| Contra-indications | * Respiratory Depression * Paralytic Ileus * Increase intracranial pressure (interferes with pupil response for neuro obs) |
| Side-effects | N&V, constipation, dry mouth, biliary spasm |
| Interactions | **Alcohol:**enhanced hypotensive/sedative effects Metoclopramide: antagonise effects of Metoclopramide on GI tract Cimetidine: inhibits opioid metabolism |
| Elimination | |
| Additional Notes | To convert dose from codeine to Morphine - divide by 10 - 60mg ⇒ 6mg |