| Mechanism | * Blocks dopamine receptors in chemoreceptor trigger zone in the brainstem * ↑ rate of gastric/duodenal emptying by relaxing pyloric sphincter |
| Typical Dose | 10mg up to TDS |
| Indications | * Hiccup, N&V in palliative care * Acute migraine * Post-cancer treatment/operative N&V |
| Contra-indications | * Parkinsonism * 3-4 days following GI surgery * Intestinal obstruction |
| Side-effects | Common: asthenia, Depression, diarrhoea, drowsiness, hypotension, Parkinsonism Rarely: confusion, arrhythmia, hallucination, hyperprolactinaemia |
| Interactions | Lithium: ↑ risk of extrapyramidal adverse effects NSAIDs: ↑ absorption of NSAIDs and their effects |
| Elimination | |
| Additional Notes | Nausea/vomiting in migraine can cause gastric stasis - decreased absorption rate of Paracetamol/Aspirin. Metaclopramide to counter this |