| Mechanism | Activation of antithrombin causing inactivation of coagulation enzymes thrombin (factor IIA), factor Xa and factor IXA |
| Typical Dose | 40mg |
| Indications | * VTE in Pregnancy * DVT prophylaxis * DVT & PE treatment in low risk of recurrence patients * Unstable Angina |
| Contra-indications | * Haemophilia/haemorrhagic disorders * Thrombocytopenia * Recent cerebral bleed * Severe liver disease * Peptic ulcer disese |
| Side-effects | * Haemorrhage * Thrombocytopenia |
| Interactions | Aspirin - increased bleeding risk |
| Elimination | |
| Additional Notes | As effective as unfractionated heparins but decreased risk of heparin-induced thrombocytopenia and act for longer. Immediate effect so suitable for acute venous events. Can be reversed by IV protamine sulphate. |