| Drug Class | Antifolate abx |
|---|---|
| Mechanism | Decreases bacterial folate production so bacteria cannot synthesise DNA |
| Typical Dose | 200mg BD |
| Indications | * UTIs (eg E coli) * Prostatitis |
| Contra-indications | * Pregnancy * Severe renal impairment * Blood disorders |
| Side-effects | Rarely: Bone marrow suppression, N&V, rash, toxic epidermal necrolysis |
| Interactions | Cyclosporins: increased risk of nephrotoxicity Pyrimethamine: increased antifolate effects |
| Elimination | |
| Additional Notes | Resistance is common |