| Mechanism | Reversible inhibition of COX-1 and COX-2 enzymes → prostaglandin synthesis |
| Typical Dose | 75-150mg OD with food |
| Indications | * Inflammatory diseases (e.g RA), Post-op pain * Pain * Pyrexia * Acute gout |
| Contra-indications | * Aspirin/NSAID hypersensitivity * Severe Heart Failure * Caution in elderly patients |
| Side-effects | GI discomfort, bleeding/ulceration, renal failure |
| Interactions | * ACE inhibitors: ↑ risk of renal impairment * SSRIs: ↑ risk of bleeding * B blockers/CCBS: NSAIDs antagonise hypotensive effects |
| Elimination | |
| Additional Notes | Risk of Gi irritation - reduce with taking with food/enteric coated tablets |