| Mechanism | Aldosterone antagonist 1. Competes for receptors in DCT cells 2. Inhibition of Na retaining action 3. Decreases potassium secreting effect |
| Typical Dose | 25-50mg or 100-200mg OD |
| Indications | * Oedema/Ascites in liver Cirrhosis * Nephrotic syndrome * CCF * Primary hyperaldosteronism |
| Contra-indications | * Hyperkalaemia/hyponatraemia * Addison’s Disease |
| Side-effects | * GI disturbance * Impotence * Gynaecomastia * Menstrual irregularities * Lethargy/headache/confusion |
| Interactions | |
| Elimination | |
| Additional Notes | |