Renal Cell Carcinoma

Cancer of the kidney that arises from the renal tubular epithelium

Two most common:

• Clear cell (75%)

• Papillary (10%)

Causes/Factors

• Age (60+)

• Male

• Obesity

• Smoking

• NSAID use

• ESRF and on dialysis

• Family history (esp Von Hippel-Lindau)

Clinical Features

Local Primary Tumour Effects

• Haematuria
• Abdominal pain

Effects of Distant Metastases

• Lung mets → SOB
• Bone mets → Bone pain

Paraneoplastic Syndromes

• Weight loss “cancer cachexia”
• Hypertension
• Polycythaemia

Diagnostic Tests

Management

Complications/red Flags