| Mechanism | Prolongs refractory period in all parts of conduction system - ↓ speed of conduction through the heart |
| Typical Dose | 200-300mg |
| Indications | Supraventricular/ventricular Arrhythmias - esp when other drugs are contra-indicated or failed V fib or pulseless VT refractory to defibrillation |
| Contra-indications | * Sinus bradycardia * SA block * Sinus node dysfunction * Thyroid dysfunction * Iodine sensitivity (contains iodine) * Pregnancy/breast feeding |
| Side-effects | * Nausea/vomiting * Jaundice * Bradycardia * Hypo/Hyperthyroidism * Sleep disturbances * Pulmonary Fibrosis * Corneal opacities and Optic neuritis |
| Interactions | * Beta blockers: ↑ risk of bradycardia/AV block/myocardial Depression * Digoxin: increased risk of toxicity (can be used for the same thing, so not sure when to give both) * Diltiazem/verapamil: ↑ risk of bradycardia/AV block/myocardial Depression (can also be used for cardioversion) |
| Elimination | |
| Additional Notes | ½ life of 36 days - interactions can occur after stopping treatment. Monitor thyroid, liver and lung function every 6 months |