Dependant
- Phenytoin
- Theophylline
- Carbamazepine
- Tacrolimus and cyclosporine
- Digoxin
- Flecainide
- Sildenafil
- Simvastatin
- SSRIs SNRIs
Enzyme inducers decrease the amount of active Warfarin and decrease its exposure (and INR)
Enzyme inhibitors increasethe amount of active Warfarin and increase its exposure (and INR)
Drugs that can inhibitP450
- Amiodarone
- Metronidazole
- Ciprofloxacin, levofloxacin
- Erythromycin, clarithromycin
- Grape fruit juice
- SSRIs- sertraline, Fluoxetine
- Sodium Valproate
- Allopurinol
Drugs that can induce P450
- Carbamazepine(self inducing)
- Phenytoin(self inducing)
- Rifampin
- St. John’s Wort
- Chronic alcohol
- Smoking