| Mechanism | Broad spec bactericidal abx - inhibits DNA gyrase (needed to coil and replicate bacterial DNA) |
| Typical Dose | 500mg BD |
| Indications | * Gram -ve infections (Salmonella, pseudomonas, campylobacter, neisseria, e coli, h. influenzae * Some gram +ve * Fistulating Crohn’s Disease * Acute Otitis Externa * Superficial bacterial eye infection (severe) * Infective Keratitis * RTIs * Acute prostatitis + Surgical prophylaxis |
| Contra-indications | Pregnancy Children Caution: Epilepsy (lowers seizure threshold) |
| Side-effects | Common: common ones Corneal deposits (reversible after completion of treatment) Arthropathy in children |
| Interactions | * Cyclosporin: ↑ risk of nephrotoxicity * Theophylline: ↑ risk of convulsion * NSAIDs: ↑ risk of convulsion * Warfarin: ↑ antocoagulant effects |
| Elimination | |
| Additional Notes | Clinically used in UTIs, resp and GI tract infections, gonorrhea and septicaemia. |