- Hyperaldosteronism - primary and secondary
- Primary: adrenal cortex hyperplasia, adenoma (intrinsic)
- Secondary - renal artery stenosis, Heart Failure, liver Cirrhosis (elsewhere in the body)
Via the RAAS - renal retion of H2O and Na+ so high blood pressure, headache and electrolyte disturbance symptoms - muscle spasms, cardiac Arrhythmias
Hypokalaemia coupled with Essential hypertension is suggestive of primary hyperaldosteronism
The first line investigation for this is a plasma aldosterone/renin ratio, which should show high aldosterone levels alongside low renin levels.