| Drug Class | Tetracycline |
|---|---|
| Mechanism | Bacteriostatic - inhibit protein synthesis |
| Typical Dose | 500mg BD |
| Indications | * Chlamydia * Rickettsia * Refractory UTI * HAP * Chronic respiratory exacerbation * Cellulitis/diabetic foot infection/leg ulcer * Rosacea * Syphilis * Pelvic inflammatory disease * Lyme disease * Malaria/anthrax |
| Contra-indications | Pregnancy |
| Side-effects | Visual disturbances + neuro symptoms, black bones/teeth (tetracyclines), Henoch-Schonlein purpura, skin reactions, N&V, diarrhoea |
| Interactions | Carbamazepine/Phenytoin: ↑ doxycycline metabolism Methotrexate: ↑ methotrexate toxicity |
| Elimination | |
| Additional Notes |