| Mechanism | * Stimulates Insulin production in pancreatic β cells - therefore only effective when some β cell activity is present * Causes depolarisation and Insulin release * Also inhibits gluconeogenesis |
| Typical Dose | 40-80mg |
| Indications | * Type II diabetes |
| Contra-indications | * Ketoacidosis * Pregnancy/breast feeding * Caution in those susceptible to hypos |
| Side-effects | * Hypoglycaemia * Weight gain * Rarely: Bone marrow suppression |
| Interactions | |
| Elimination | |
| Additional Notes | Often combined with Metformin as a duotherapy |