Mechanism | Lowers plasma glucose concentration: * Glucose transport into fat and muscle cells * Stimulating glycogen synthesis * Inhibiting gluconeogenesis |
Typical Dose | (According to requirements) |
Indications | * Diabetes type I (and 4th line for TII) * Ketoacidosis * Hyperglycaemic hyperosmotic non-ketotic coma * Emergency treatment of Hyperkalaemia |
Contra-indications | Caution in renal impairment |
Side-effects | * Hypoglycaemia * Weight gain * Oedema |
Interactions | B-blockers - mask warning signs of Hypoglycaemia |
Elimination | |
Additional Notes | See Diabetes management for the different types of insulin dose and how to prescribe |