| Mechanism | Inhibits gastric acid secretion by dose-dependent inhibition of proton pump of gastric parietal cells (blocks H+/K+ pump ATPase enzyme in parietal cells) |
| Typical Dose | 20-40mg OD |
| Indications | * GORD * dyspepsia * Oesophagitis * GI ulcers * H. pylori eradication * Zollinger-Ellison syndrome (gastrin-secreting tumour or hyperplasia of the islet cells in the pancreas) |
| Contra-indications | Caution in: * Liver disease * Breast feeding/Pregnancy |
| Side-effects | * GI disturbances * Headache * Long term use associated with Hypomagnesemia |
| Interactions | Inhibits cytochrome P450 ↑ plasma concentration of Phenytoin, Warfarin |
| Elimination | 80% renal, 20% faecal |
| Additional Notes | May mask symptoms of Gastric Cancer |