| Mechanism | * Acts on β1 receptors in the heart * ↓ HR and force of contraction - ↓ work load * ↓ rennin production by kidneys - anti-HNT * ↓ conduction/AP initiation in heart - anti-arrhythmic effect |
| Typical Dose | 25-100mg OD |
| Indications | * HTN * Angina * Supraventricular dysrhythmias * MI prophylaxis * Migraine prophylaxis |
| Contra-indications | asthma, HF, 2nd/3rd degree Heart Block, bradycardia, COPD |
| Side-effects | * Lethargy * Bradycardia * AV block |
| Interactions | Do not use with Diltiazem or verapamil (CCBs) as increased risk of bradycardia - use an α blocker instead Insulin - masks symptoms of Hypoglycaemia |
| Elimination | 50% urine 50% faeces |
| Additional Notes | Atenolol selective for β1 receptors except in high doses |